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RAP opportunity at National Institute of Standards and Technology     NIST

Improving Measurement Assurance of In Vitro Toxicity Assays


Material Measurement Laboratory, Biosystems and Biomaterials Division

opportunity location
50.64.41.C0251 Gaithersburg, MD

NIST only participates in the February and August reviews.


name email phone
John Timothy Elliott 301.975.8551
Bryant C. Nelson 301.975.2517
Elijah Joel Petersen 301.975.8142


In vitro and acellular assays can play an important role in determining the potential toxicity of compounds to humans and ecological receptors. To establish the extent of the biological relevance of these assays in predicting the effects in physiological systems, a high-level of confidence in the precision and robustness of these assay measurements is required. This postdoctoral opportunity features an opportunity to comprehensively examine an in vitro assay or assays to improve the repeatability and interlaboratory agreement of the assay results. This could entail using cause-and-effect analysis to understand sources of variability in the assay, designing new plate layouts that include key process control measurements, and utilizing appropriate statistical analyses to understand the assay results and their uncertainties. This process should lead to improvements in the comparability and reproducibility of assay results within and between laboratories.

key words
cell-based assays; measurement science; cytotoxicity; high quality assays; biological reference methods


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants


Base Stipend Travel Allotment Supplementation
$82,764.00 $3,000.00
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