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RAP opportunity at National Institute of Standards and Technology     NIST

Advanced computational modeling techniques to enable fast screening of RNA biopharmaceutical products


Material Measurement Laboratory, Biomolecular Measurement Division

opportunity location
50.64.51.C0395 Gaithersburg, MD

NIST only participates in the February and August reviews.


name email phone
Christina Bergonzo (240)314-6333
John P. Marino 240.314.6361


There has been a recent emergence of RNA biotherapeutics; that is, small RNAs used as drug therapies. Chemical modifications to RNA have been implemented to increase efficacy of nucleic acid delivery. These modifications effect degradation resistance and render them unrecognizable to the immune system. However, not much is known about how these chemical modifications affect structure-function relationships. We propose to develop robust computational modeling in conjunction with experimental NMR and SAXS measurements to understand the consequences of chemical modification on structural durability of short RNA oligomers, which function as RNA aptamer drugs.

key words
RNA biotherapeutics; aptamer drugs; chemical modifications; structure-function; computational modeling; NMR; SAXS


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants


Base Stipend Travel Allotment Supplementation
$82,764.00 $3,000.00
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