Research focuses on the development and application of multi-detector, multi-dimensional macromolecular separation science techniques. Topics include (1) designing macromolecular two-dimensional liquid chromatography (2D-LC) separations to characterize the physicochemical phase space inhabited by complex polymers, blends, and novel materials; (2) physicochemical characterization of nanoparticles by SEC, HDC, AF4, H5F separations coupled to e.g., MALS, QELS, ICP-MS, etc.; (3) non-empirical, first-principles-based development of novel "interactive" macromolecular LC methods; (4) quantitative determination of structural influences on solution flexibility of small sugars (mono-, di-, and oligosaccharides); (5) physicochemical characterization of polyelectrolytes; (6) determining structural and related influences on transient elongational flow-induced polymer degradation; and (7) thermodynamics of dilute polymer solutions. Reseach will emphasize applications to macromolecular, analytical, carbohydrate, and nanoparticle disciplines.
Striegel AM: Absolute molar mass determination in mixed solvents. 2. SEC/MALS/DRI in a mix of two "nearly-isovirial" solvents. Analytica Chimica Acta 1231:340369, 2022
Striegel AM: Method development in interaction polymer chromatography. Trends in Analytical Chemistry 130:115990, 2020
Pitkänen L, Montoro Bustos AR, Murphy KE, Winchester MR, Striegel AM: Quantitative characterization of gold nanoparticles by size-exclusion and hydrodynamic chromatography, coupled to inductively coupled plasma mass spectrometry and quasi-elastic light scattering. Journal of Chromatography A 1511: 59-67, 2017
Pitkänen L, Striegel AM: Polysaccharide characterization by hollow-fiber flow field-flow fractionation with on-line multi-angle static light scattering and differential viscometry. Journal of Chromatography A 1380:146-155, 2015
Separation science; Multiple detection; Multi-dimensional; Macromolecules; Polymers, Carbohydrates; Nanoparticles; Polysaccharides; Liquid chromatography;