Development of quantitative structure-property relationships for polymers has been largely limited due to the inability to systematically control polymer sequence especially under real-world conditions where process history, crystallization, and degradation cannot be neglected.  This project seeks to tackle this problem through the rational design of model polymer systems with varying degrees of sequence control, including well-defined, periodic, gradient, and block monomer sequences achieved through controlled polymerization methods.   The polymers will then be subjected to a variety of conditions, such as degradation, and undergo quantitative analysis including rheology, DSC, scattering, etc. Concurrently, computational modeling will be used to predict both structure-property relationships and degradation rates based on the number and distribution of the monomers with the aforementioned analysis serving as validation.  Proposals will focus on either the synthetic or computational approaches to these challenges but should address the integration of synthesis, simulation, and polymer metrology for sequence-controlled polymers.