NRC Research and Fellowship Programs
Fellowships Office
Policy and Global Affairs

Participating Agencies

  sign in | print

RAP opportunity at National Institute of Standards and Technology     NIST

Screening Cell Response to Tissue Scaffold Properties


Material Measurement Laboratory, Biosystems and Biomaterials Division

opportunity location
50.64.41.B6517 Gaithersburg, MD

NIST only participates in the February and August reviews.


name email phone
Nancy J Lin 301.975.4935
Carl George Simon 301.975.8574


We will develop methods to explore cell response to tissue scaffolds that mimic natural bone through inclusion of a calcium phosphate phase. Calcium phosphate is the main component of the mineral phase of bone, and osteoblasts in vivo generate new bone in tight apposition to calcium phosphate implants. Polymeric scaffolds containing a calcium phosphate ceramic phase such as hydroxyapatite, tricalcium phosphates, amorphous calcium phosphate, or hydroxyapatite nanoparticles will be fabricated. Osteoblasts will be cultured in the scaffolds and the ability of the multiphase materials to support bone generation will be evaluated. Methods for fabricating scaffolds in the forms of arrays or gradients will be pursued to yield new methodologies for screening osteoblast performance in multiphase tissue scaffolds. Mechanisms of action will be explored including release of Ca and P ions, protein adsorption/conformation, changes in calcium phosphate crystallinity, and effects of surface chemistry and topology.

key words
Cell biology; Composites; Polymers; Tissue scaffolds; Osteoblast; Bone; Tissue engineering; Regenerative medicine;


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants


Base Stipend Travel Allotment Supplementation
$82,764.00 $3,000.00
Copyright © 2024. National Academy of Sciences. All rights reserved.Terms of Use and Privacy Policy