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RAP opportunity at National Institute of Standards and Technology     NIST

Multiplexed Biomolecular Measurements


Material Measurement Laboratory, Biosystems and Biomaterials Division

opportunity location
50.64.41.B7203 Gaithersburg, MD

NIST only participates in the February and August reviews.


name email phone
David J. Ross 301.975.2525
Wyatt Neil Vreeland 202-550-7183


Biological systems are inherently complex-the quantitative characterization of the state of such a system requires simultaneous measurement of many properties. Our group is working to develop the measurement science and technology to make multiplexed biomolecular measurements practical, while also working to develop the standards and measurement assurance approaches needed to have confidence in those measurements. We focus on genome-scale multiplexed measurements of nucleic acids and proteins, using approaches such as microarrays and ultra-high throughput “next-generation” DNA sequencing, along with multiplexed affinity-based protein measurements. Technology development is based on microfluidic systems for cell manipulation and culture, and sample preparation. Measurement assurance is based on a large set of spike-in controls (developed collaboratively with the External RNA Control Consortium) and experiment designs relying on titrations of complex mixtures.


key words
Bioinformatics; Biostatistics; Gene expression; High throughput sequencing; Micro RNA; Microfluidics; Molecular biology; Multiplexed bioassays; Next generation sequencing;


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants


Base Stipend Travel Allotment Supplementation
$82,764.00 $3,000.00
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