NRC Research and Fellowship Programs
Fellowships Office
Policy and Global Affairs

Participating Agencies

  sign in | print

RAP opportunity at National Institute of Standards and Technology     NIST

Precision Measurements of Cancer Biomarkers for Liquid Biopsies


Material Measurement Laboratory, Biosystems and Biomaterials Division

opportunity location
50.64.41.C0094 Gaithersburg, MD

NIST only participates in the February and August reviews.


name email phone
Hua-Jun He 301-975-8518


The detection of cancer biomarkers in body fluids, referred to as "Liquid Biopsy", has become a cutting-edge technology that has the potential to non-invasively screen and diagnose cancer at early stage, monitor tumor progression, and evaluate therapy responses. The molecular profiles gathered from circulating tumor DNA (ctDNA) such as gene alteration and DNA methylation can be further complemented with the analysis of circulating tumor cells (CTCs), RNA, proteins, and exosomes. NIST has collaborations with the National Cancer Institute laboratories that are specialized in cancer biomarker discovery and characterization. Potential projects include the effect of altered nucleosome positioning and aberrant DNA methylation on the early detection of cancer. Nucleosome positioning and DNA methylation profiling can potentially be used for quantitative estimation of tumor burden and tissue-of-origin mapping in liquid biopsies. Additional projects include the application of PCR-free electrochemical and other emerging detection methods for the sensitive and selective measurements of cancer biomarkers in liquid biopsies. Applicants with experience and interests in the development of digital PCR, next-generation sequencing methods, other PCR-free methods or bioinformatic analysis for the sensitive measurement of rare allele genetic alterations or epigenetics alterations are encouraged to apply.

key words
Cancer biomarker; Liquid biopsy; Circulating tumor DNA; Nucleosome positioning; DNA methylation; PCR; NGS; Bio-sensing; Cancer detection


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants


Base Stipend Travel Allotment Supplementation
$82,764.00 $3,000.00
Copyright © 2024. National Academy of Sciences. All rights reserved.Terms of Use and Privacy Policy