Opportunity at National Institute of Standards and Technology NIST
Improving Measurement Assurance of In Vitro Toxicity Assays
Material Measurement Laboratory, Biosystems and Biomaterials Division
Please note: This Agency only participates in the February and August reviews.
|John Timothy Elliott
|Bryant C. Nelson
|Elijah Joel Petersen
In vitro and acellular assays can play an important role in determining the potential toxicity of compounds to humans and ecological receptors. To establish the extent of the biological relevance of these assays in predicting the effects in physiological systems, a high-level of confidence in the precision and robustness of these assay measurements is required. This postdoctoral opportunity features an opportunity to comprehensively examine an in vitro assay or assays to improve the repeatability and interlaboratory agreement of the assay results. This could entail using cause-and-effect analysis to understand sources of variability in the assay, designing new plate layouts that include key process control measurements, and utilizing appropriate statistical analyses to understand the assay results and their uncertainties. This process should lead to improvements in the comparability and reproducibility of assay results within and between laboratories.
cell-based assays; measurement science; cytotoxicity; high quality assays; biological reference methods
Open to U.S. citizens
Open to Postdoctoral applicants