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RAP opportunity at National Institute of Standards and Technology     NIST

Super-resolution Imaging of Single-Molecules as a Tool for Nanoscale Soft Material Measurements


Physical Measurement Laboratory, Microsystems and Nanotechnology Division

opportunity location
50.68.02.C0271 Gaithersburg, MD 20899

NIST only participates in the February and August reviews.


name email phone
James Alexander Liddle 301.975.6050


Single-molecule fluorescence microscopy has revolutionized our ability to probe structure-function relationships in biological systems, and was recognized with the Nobel Prize in Chemistry in 2014.  We are investigating the application of similar methods to soft material systems to provide insights into their nanoscale behavior that cannot be obtained in any other way.  We are developing unique instrumentation and methods to simultaneously determine the position, orientation, mobility, lifetime, and spectra of individual molecules in polymer and composite materials to probe structure-property relationships at the nanoscale.  The single-molecule imaging lab is part of the Microsystems and Nanotechnology Division, where we develop instrumentation beyond the state of the art. Our research program offers a supportive, highly-multidisciplinary environment coupled with outstanding experimental resources.


Simultaneous single-molecule localization and orientation microscopy reveals nanoscale structure and deformation in soft materials, Muzhou Wang, Marcelo Davanco, James M. Marr, Jeffrey W. Gilman, J. Alexander Liddle, Mater. Horiz. (2019)

Super-resolution Optical Measurement of Nanoscale Photoacid Distribution in Lithographic Materials, A. J. Berro, A. J. Berglund, P. T. Carmichael, J. S. Kim, J. A. Liddle, ACS Nano, 6, 9496 (2012)

key words
Super-resolution optical microscopy; single-molecule imaging; fluorescence; nanoscopy; soft matter; polymer dynamics


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants


Base Stipend Travel Allotment Supplementation
$82,764.00 $3,000.00
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