NRC Research Associate Programs
Fellowships Office
Policy and Global Affairs

Participating Agencies

  sign inOpen Printer View

RAP opportunity at National Institute of Standards and Technology     NIST

Single Molecule Biosensors


Physical Measurement Laboratory, Microsystems and Nanotechnology Division

opportunity location
50.68.02.C0553 Gaithersburg, MD 20899

NIST only participates in the February and August reviews.


name email phone
Joseph William Robertson 301.975.2506


Nanopores offer the potential to study a wide range of biophysical processes that includes kinetics of molecular transport, differences in unfolding pathways, protein stability and the free energy profiles of DNA-protein and RNA-protein binding. In addition to providing a tool for fundamental protein characterization, nanopore measurement systems can also be used to study polymer confinement at the single molecule limit.

Chemical detection with a nanopore transducer requires external control of mass transport, the capture of the analyte from bulk solution and the physical and chemical interactions within the cavity to characterize the confined molecule. We are developing new tools using electronics and optics to manipulate the local environment with nanometer precision and nanosecond to probe the critical physicochemical interactions which provide insight to the mechanisms of molecular transport and nanopore sensing.

Selected References

  • Single Molecule Nanopore Spectrometry for Peptide Detection, Chavis, A. E., Brady, K. T., Hatmaker, G. A., Angevine, C. E., Kothalawala, N., Dass, A., Robertson, J. W. F., and Reiner, J. E., ACS Sensors 2, 1319–1328 (2017)
  • The Utility of Nanopore Technology for Protein and Peptide Sensing, Robertson, J. W. F. and Reiner, J. E., Proteomics 18, 1800026 (2018).

key words
Biosensors; DNA; membranes; proteins; nanopore; nanotechnology; single-molecule sensors; Coulter counter; electrophysiology; electrochemistry; local surface plasmon resonance


Citizenship:  Open to U.S. citizens
Level:  Open to Postdoctoral applicants


Base Stipend Travel Allotment Supplementation
$82,764.00 $3,000.00
Copyright © 2024. National Academy of Sciences. All rights reserved.Terms of Use and Privacy Policy