Materials hybridization (hetero-material configuration) at smaller scale, taking to atomic scale, offers unprecedented opportunities for optimizing materials functionality (electronic, thermal, chemical, and mechanical) at reduced material consumption and potentially reduced materials qualification costs. Multi-material heterogeneity through efficient design of materials interface morphology and processing protocol for precise placement of atoms/molecules via appropriate processing routes are desired. Our emphasis is in integrating scale-appropriate (atomic, meso, continuum) materials modeling with processing science towards developing scalable materials processing approaches and understanding the physics of materials response to device performance. Our interest is in employing innovative materials modeling (DFT, MD, tight binding DFT, meso-scale, continuum mechanics) to facilitate developing scalable nano-manufacturing approaches, such as printing, laser or e-beam processing. Creative material metrology in conjunction of the materials modeling is also of interest.