This research focuses on developing new applications of high resolution/accurate mass (HRAM) mass spectrometry for environmental, forensic, and nutritional analyses. HRAM mass spectrometry instrumentation has pushed the limits of mass detection to spectral resolutions over 100,000, allowing for specific mass determination and unknown compound identification. Analytical methods and novel data-processing tools need to be developed to embrace these new techniques and further elevate their capabilities. Instrumentation available for this research includes ion trap, Orbitrap, and time-of-flight mass spectrometric technologies. Research interests include (1) development of novel approaches for the non-target screening of complex chemical systems; (2) fundamental research of HRAM-MS technologies and affiliated hyphenated analysis techniques such as, two-dimensional liquid chromatography coupled to HRAM-MS for chemical fingerprinting of foods; and (3) investigation of chemometric analytical methods for the data handling and processing of HRAM mass spectral data.

 

key words

High resolution mass spectrometry; Accurate mass; Chemometrics; Chromatography; Clinical; Dietary supplements; Food; Forensics;

Citizenship:  Open to U.S. citizens

Level:  Open to Postdoctoral applicants