This project’s focus is to develop light-scattering nanoscopy methods for rapid, multi-attribute characterization of gene therapy particles at the single particle level. Emerging gene therapy treatments use gene delivery particles, such as viral vectors and non-viral carriers, to cure intractable diseases. But, because these complex nano-bioparticles are difficult to produce and accurately characterize, manufactured particles suffer heterogeneity issues which hinder treatment efficacy and safety. To speed treatment development and improve efficacy and safety we are developing interferometric optical microscopes to provide physical measurements (e.g. mass, size, concentration, composition) of individual gene delivery particles.

We are seeking candidates with backgrounds in optics, microscopy, instrumentation, optical modelling, and/or biophysics. Candidates will work closely with a collaborative, multidisciplinary team of researchers to design, build, and model novel instrumentation to advance our capabilities for characterizing gene delivery systems at the single-particle level. There will also be opportunities for interested candidates to develop advanced data processing techniques and gain experience working with gene delivery particles.

key words

microscopy; light scattering; gene therapy; imaging; interferometry; nanoparticles; gene delivery particles; viral vectors; lipid nanoparticles; biophotonics

Citizenship:  Open to U.S. citizens

Level:  Open to Postdoctoral applicants